Why the study?
Does Griffonia simplicifolia I lectin binding demonstrate reduced microvascular density in hypertensive rat models compared to normotensive controls?
Population
Rats with chronic reduced renal mass hypertension and normotensive sham-operated control rats, as well as…
Comparison
Incubation of cremaster and spinotrapezius… vs Normotensive control rats.
Design
Preclinical
Authors
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Lectin binding enables perfusion-independent rarefaction assessment in hypertensive models; extends prior observations but leaves open human translation.
Does Griffonia simplicifolia I lectin binding demonstrate reduced microvascular density in hypertensive rat models compared to normotensive controls?
Lectin binding is a useful tool for assessing microvessel density independent of perfusion state, demonstrating that hypertension-induced rarefaction is not evenly distributed across vascular beds and can be influenced by dietary salt intake.
Greene et al. (1990) studied this question.
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