Population
Nine-week-old Sprague-Dawley reduced renal mass rats
Comparison
High sodium diet for 4 weeks followed by low… vs Low sodium diet for 4 or 8 weeks, or baseline…
Design
Preclinical
Follow-up
up to 8 weeks
Authors
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Hypothesis-generating for sodium restriction in hypertension; clinical translation and human trials needed before practice change.
Modulation of the renin-angiotensin system via dietary sodium changes can reverse microvascular rarefaction in reduced renal mass hypertensive rats.
Rieder et al. (1997) studied this question.
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