Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1989Circulation ResearchOpen Access

Effects of chronic hypertension and its reversal on arteries and arterioles.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the reversal of chronic renal hypertension normalize structural alterations in arteries and arterioles in a rat model?

Population

Rats with one-kidney, one-clip hypertension, rats in which the clip was removed after 8 weeks, and controls.

Comparison

Removal of the clip after 8 weeks to reverse… vs Rats with maintained one-kidney, one-clip…

Design

Preclinical

Follow-up

12 weeks after initial surgery

Authors

DSD. L. StacyResearch Triangle Park FoundationRPRussell L. PrewittLouisiana State University

Discussion

Loading...

Member takes

Implication

Incomplete arteriolar restoration after hypertension reversal in rats cautions against assuming full microvascular normalization in patients; leaves open targeted therapies beyond BP control.

Structured PICO

Does the reversal of chronic renal hypertension normalize structural alterations in arteries and arterioles in a rat model?

P
Population
Rats with one-kidney, one-clip hypertension (1K1C), rats in which the clip was removed after 8 weeks (1KNT), and controls.
I
Intervention
Removal of the clip after 8 weeks to reverse hypertension
C
Comparator
Rats with maintained one-kidney, one-clip hypertension (1K1C) and normotensive controls
O
Outcome
In vivo arteriolar and venular dimensions in the cremaster muscle, medial-intimal hypertrophy in aortae and arterioles, and heart weightsurrogate

Reversal of chronic renal hypertension in a rat model normalizes structural changes in the heart and large vessels, but microvascular arteriolar changes are only partially restored.

Cite This Study

Stacy et al. (1989) studied this question.

synapsesocial.com/papers/6a6f9bd85d37378ac1dcab3dhttps://doi.org/10.1161/01.res.65.4.869

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Hypertension and Its Reversal on the Thoracic Aorta of Male and Female Rats1971 · 213 citations
  2. 2Hyperplasia of Rat Arteries Smooth Muscle Cells Associated with Development and Reversal of Renal Hypertension1980 · 33 citations
  3. 3The Microcirculation in Hypertension: Which Are the Resistance Vessels?1987 · 6 citations
  4. 4THE EFFECTS OF RENAL HYPERTENSION ON THE VESSELS OF THE EARS OF RABBITS1942 · 13 citations
  5. 5Histometrical Investigations of Arteries in Reference to Arterial Hypertension1962 · 208 citations