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October 1, 1987AJP Heart and Circulatory Physiology

Alterations in the microvasculature of one-kidney, one-clip hypertensive rats

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Population

One-kidney, one-clip (1K-1C) hypertensive rats and uninephrectomized controls

Comparison

Renal artery stenosis (1K-1C model) vs Uninephrectomized controls

Design

Preclinical

Follow-up

8-9 weeks

Authors

HHH HashimotoEastern Virginia Medical SchoolRPRussell L. PrewittLouisiana State UniversityCEClark W. EfawEastern Virginia Medical School

Discussion

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Implication

Supports staged microvascular changes in experimental renal hypertension; leaves open translation to human disease and therapy.

Structured PICO

P
Population
One-kidney, one-clip (1K-1C) hypertensive rats and uninephrectomized controls
I
Intervention
Renal artery stenosis (1K-1C model)
C
Comparator
Uninephrectomized controls
O
Outcome
Microcirculation alterations (inside and outside diameters of first through fourth-order arterioles before and after vasodilation with 10(-4) M adenosine)surrogate

In a rat model of renal hypertension, initial microvascular changes are driven by vasoconstriction of the smallest arterioles, whereas structural alterations (rarefaction and lumen reduction) become predominant later.

Cite This Study

Hashimoto et al. (1987) studied this question.

synapsesocial.com/papers/6a6f9be835aa2c282ce0f393https://doi.org/10.1152/ajpheart.1987.253.4.h933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuated microvascular alterations in coarctation hypertension1989 · 16 citations
  2. 2Effects of chronic hypertension and its reversal on arteries and arterioles.1989 · 42 citations
  3. 3<u>In vivo</u>Venular Changes with the Development of One-Kidney, one-Clip Hypertension in the Rat1986 · 1 citations
  4. 4Progressive microvascular alterations with the development of renovascular hypertension.1984 · 38 citations
  5. 5Hemodynamic and microvascular responses in the hindquarters during the development of renal hypertension in rats. Evidence for the involvement of an autoregulatory component.1984 · 26 citations