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January 1, 1984Hypertension

Progressive microvascular alterations with the development of renovascular hypertension.

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Population

Normotensive and renovascular hypertensive rats

Comparison

Surgery to induce renovascular hypertension vs Normotensive rats

Design

Preclinical

Follow-up

4 weeks

Authors

IJIrving G. JoshuaUniversity of LouisvilleDWDavid L. WiegmanUniversity of LouisvillePHP. D. HarrisAmerican Museum of Natural History

Discussion

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Implication

Hypothesis-generating for progressive arteriolar remodeling in renovascular hypertension; human studies required before clinical relevance.

Structured PICO

P
Population
Normotensive and renovascular hypertensive rats
I
Intervention
Surgery to induce renovascular hypertension
C
Comparator
Normotensive rats
O
Outcome
Norepinephrine-induced changes in diameters of first- (1A), second- (2A), and third-order (3A) arterioles in exposed cremaster musclessurrogate

Renovascular hypertension induces progressive structural constriction and altered responsiveness in skeletal muscle arterioles, starting distally and progressing proximally.

Cite This Study

Joshua et al. (1984) studied this question.

synapsesocial.com/papers/6a6f9be835aa2c282ce0f398https://doi.org/10.1161/01.hyp.6.1.61
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium Modulation of Microvascular Sensitivity during Renovascular Hypertension1981 · 2 citations
  2. 2Arteriolar closure mediated by hyperresponsiveness to norepinephrine in hypertensive rats1979 · 78 citations
  3. 3The Haemodynamic Consequences of Adaptive Structural Changes of the Resistance Vessels in Hypertension1971 · 269 citations
  4. 4Effects of hypertension on the static mechanical properties and chemical composition of the rat aorta1976 · 166 citations
  5. 5Vascular Resistance and Reactivity in Hypertensive Rats2008 · 63 citations