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January 1, 1989AJP Heart and Circulatory Physiology

Attenuated microvascular alterations in coarctation hypertension

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Why the study?

Does coarctation hypertension induce pressure- or flow-independent microvascular alterations in a normotensive skeletal muscle bed in rats?

Population

Rats with coarctation hypertension produced by placing a silver clip around the abdominal aorta above the…

Comparison

Coarctation hypertension model vs Control rats

Design

Preclinical

Follow-up

Up to 8 weeks

Authors

DSD. L. StacyResearch Triangle Park FoundationRPRussell L. PrewittLouisiana State University

Discussion

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Implication

Arteriolar remodeling in hypertension appears pressure- or flow-dependent; leaves open translation beyond this animal model.

Structured PICO

Does coarctation hypertension induce pressure- or flow-independent microvascular alterations in a normotensive skeletal muscle bed in rats?

P
Population
Rats with coarctation hypertension produced by placing a silver clip around the abdominal aorta above the branches of the renal arteries
I
Intervention
Coarctation hypertension model
C
Comparator
Control rats
O
Outcome
Microvascular alterations (resting diameters, vascular tone, medial-intimal area, and density of small arterioles) in the cremaster musclesurrogate

Microvascular alterations in a protected vascular bed during coarctation hypertension lack structural reductions in diameter, suggesting that most arteriolar alterations in renal hypertension are pressure or flow dependent.

Cite This Study

Stacy et al. (1989) studied this question.

synapsesocial.com/papers/6a907d8ec63bb9fb07dd9499https://doi.org/10.1152/ajpheart.1989.256.1.h213

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased arteriolar wall-to-lumen ratio in a normotensive vascular bed in coarctation hypertension1985 · 18 citations
  2. 2Alterations in the microvasculature of one-kidney, one-clip hypertensive rats1987 · 47 citations
  3. 3Pressure-independent arteriolar rarefaction in hypertension1991 · 30 citations
  4. 4Morphometric evidence for non-pressure-related arterial wall thickening in hypertension.1988 · 30 citations
  5. 5Increased resistance and impaired maximal vasodilation in normotensive vascular beds of rats with coarctation hypertension.1979 · 31 citations