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May 1, 1988Circulation Research

Morphometric evidence for non-pressure-related arterial wall thickening in hypertension.

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Why the study?

Does coarctation of the abdominal aorta cause non-pressure-related vascular wall thickening in normotensive hindquarters of rats?

Population

43 rats (14 with coarcted abdominal aorta, 16 sham-coarcted, 13 two-kidney, one-clip Goldblatt hypertensive)

Comparison

Coarctation of the abdominal aorta upstream to… vs Sham-coarcted rats and two-kidney, one-clip…

Design

Preclinical

Follow-up

4 to 6 weeks

Authors

JLJ L LiuUniversity of Alabama at BirminghamSBSanford P. BishopRutgers, The State University of New JerseyHOH. W. OverbeckWest Virginia School of Osteopathic Medicine

Discussion

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Implication

Supports non-pressure mechanisms of vascular remodeling in coarctation models; hypothesis-generating for human hypertension, requires prospective validation.

Structured PICO

Does coarctation of the abdominal aorta cause non-pressure-related vascular wall thickening in normotensive hindquarters of rats?

P
Population
43 rats (14 with coarcted abdominal aorta, 16 sham-coarcted, 13 two-kidney, one-clip Goldblatt hypertensive)
I
Intervention
Coarctation of the abdominal aorta upstream to the renal arteries
C
Comparator
Sham-coarcted rats and two-kidney, one-clip (Goldblatt) hypertensive rats
O
Outcome
Morphometric measurements of vascular wall thickening (medial area, medial thickness, medial thickness-to-lumen radius ratios) in abdominal aorta, femoral artery, and renal arteriolessurrogate

The study provides morphometric evidence that vascular wall thickening in hypertension can occur via non-pressure-related mechanisms.

Cite This Study

Liu et al. (1988) studied this question.

synapsesocial.com/papers/6a815ac19ec2426b2722eaaahttps://doi.org/10.1161/01.res.62.5.1001

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased resistance and impaired maximal vasodilation in normotensive vascular beds of rats with coarctation hypertension.1979 · 31 citations
  2. 2Effects of graded renal artery constriction on blood pressure, renal artery pressure, and plasma renin activity in Goldblatt hypertension.1984 · 40 citations
  3. 3Regional Circulations in Experimental Coarctation of the Aorta in Conscious Dogs1985 · 5 citations
  4. 4The effects of alpha-methyldopa on cardiac hypertrophy in spontaneously hypertensive rats: ultrastructural, stereological, and morphometric analysis1979 · 77 citations
  5. 5Cardiac hypertrophy and antihypertensive therapy1977 · 257 citations