Why the study?
Does the reversal of hypertension normalize structural and compositional changes in the thoracic aorta of male and female rats?
Population
Male and female rats
Comparison
Hypertension for 10 weeks followed by its reversal vs Normotensive controls
Design
Preclinical
Follow-up
10 weeks (hypertension phase)
Authors
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May incompletely reverse aortic remodeling after BP normalization in males; leaves open sex-specific adjunctive strategies.
Does the reversal of hypertension normalize structural and compositional changes in the thoracic aorta of male and female rats?
Hypertension induces partially irreversible structural and compositional changes in the thoracic aorta of rats, with notable sex differences upon blood pressure normalization, suggesting limitations to the benefits of blood pressure reduction alone.
Harvey Wolinsky (1971) studied this question.
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