Why the study?
Does local overexpression of tPA via an adenoviral vector prevent arterial thrombosis in an in vivo rabbit model?
Population
in vivo rabbit model of arterial thrombosis (stasis/injury model in the common femoral artery)
Comparison
Local overexpression of tissue plasminogen… vs Viral and nonviral controls
Design
Preclinical
Authors
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Local tPA gene delivery prevents thrombosis in rabbits without systemic effects; hypothesis-generating and leaves open human translation.
Does local overexpression of tPA via an adenoviral vector prevent arterial thrombosis in an in vivo rabbit model?
Local gene therapy with tPA prevents arterial thrombosis in a rabbit model without causing systemic coagulopathy, offering a potential strategy for localized thromboresistance.
Waugh et al. (1999) studied this question.
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