Why the study?
Does recombinant desulfatohirudin compared to heparin reduce plasma levels of fibrinopeptide A and prothrombin fragment F1.2 in patients with unstable angina?
Population
163 patients with unstable angina (n=50 in heparin group, n=113 in r-hirudin group)
Comparison
Recombinant desulfatohirudin infusion at 0.05… vs Heparin infusion
Design
RCT, randomized to one of two doses of heparin or one of four doses of r-hirudin
Follow-up
24 hours
Authors
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Hirudin suppresses thrombin action more than heparin but not generation in unstable angina; extends evidence on differential thrombin inhibition.
Does recombinant desulfatohirudin compared to heparin reduce plasma levels of fibrinopeptide A and prothrombin fragment F1.2 in patients with unstable angina?
Recombinant desulfatohirudin is a more potent inhibitor of thrombin action but a less effective inhibitor of thrombin generation compared to heparin in patients with unstable angina.
Rao et al. (1996) studied this question.
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