April 1, 2000Journal of Virology

Evolution of the Sabin Strain of Type 3 Poliovirus in an Immunodeficient Patient during the Entire 637-Day Period of Virus Excretion

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Population

A 20-year-old female hypogammaglobulinemic patient (n=1)

Design

Case_report

Follow-up

637 days

Authors

JMJavier MartínScripps Research Institute GDGlynis DunnNational Institute for Biological Standards and Control RHRobin HullNational Institute for Biological Standards and Control

Discussion

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Implication

May indicate persistent shedding risk in immunodeficient hosts; leaves open full reversion potential and surveillance needs.

Structured PICO

Population

A 20-year-old female hypogammaglobulinemic patient (n=1)

Intervention

Monotypic Sabin 3 oral poliovirus vaccine

Outcome

Evolution of Sabin 3 poliovirus (antigenic properties, virulence, temperature sensitivity, and nucleotide sequence differences) over the entire period of virus excretionsurrogate

In an immunodeficient patient, the Sabin 3 poliovirus evolved at a rate similar to wild-type transmission over 637 days without full reversion of attenuated phenotypes, providing insight into the risks of long-term viral excretion.

Cite This Study

Martín et al. (2000) studied this question.

synapsesocial.com/papers/6a6f9d9e75498292b708fe16 https://doi.org/10.1128/jvi.74.7.3001-3010.2000

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Evolution of the Sabin Strain of Type 3 Poliovirus in an Immunodeficient Patient during the Entire 637-Day Period of Virus Excretion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evolution of the Sabin Strain of Type 3 Poliovirus in an Immunodeficient Patient during the Entire 637-Day Period of Virus Excretion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider