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April 1, 1986Journal of General Virology

Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary Vaccinee

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Why the study?

How does the Sabin strain of type 3 poliovirus evolve antigenically and molecularly during excretion by a primary vaccinee?

Population

A 4-month-old child immunized with a vaccine containing the Sabin live attenuated vaccine strains of all…

Design

Case_report

Follow-up

73 days

Authors

PMP. D. MinorNational Institute for Biological Standards and ControlAJA. JohnRutgers, The State University of New JerseyMFMichael A. J. FergusonBrigham and Women's Hospital

Discussion

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Implication

Extended excretion of recombinant poliovirus strains may warrant surveillance vigilance; single case leaves open transmission risks.

Structured PICO

How does the Sabin strain of type 3 poliovirus evolve antigenically and molecularly during excretion by a primary vaccinee?

P
Population
A 4-month-old child immunized with a vaccine containing the Sabin live attenuated vaccine strains of all three serotypes of poliovirus (n=1)
I
Intervention
Sabin live attenuated poliovirus vaccine
O
Outcome
Antigenic and molecular evolution of the Sabin strain of poliovirus type 3 during the period of virus excretionsurrogate

The Sabin type 3 poliovirus vaccine strain undergoes rapid molecular evolution through recombination and point mutations during excretion in a primary vaccinee, while maintaining main immunodominant antigenic site stability.

Cite This Study

Minor et al. (1986) studied this question.

synapsesocial.com/papers/6a6f59bae5469ee92be055aahttps://doi.org/10.1099/0022-1317-67-4-693
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of Strains of Type 3 Poliovirus by Oligonucleotide Mapping1982 · 48 citations
  2. 2Comparative biochemical studies of type 3 poliovirus1980 · 79 citations
  3. 3Principal and Subsidiary Antigenic Sites of VP1 Involved in the Neutralization of Poliovirus Type 31985 · 78 citations
  4. 4Neutralization Epitopes on Poliovirus Type 3 Particles: an Analysis Using Monoclonal Antibodies1984 · 49 citations
  5. 5Trypsin sensitivity of the Sabin strain of type 1 poliovirus: cleavage sites in virions and related particles1985 · 70 citations