Population
Rat embryo fibroblast cell line CREF and human cell line TE85
Design
Preclinical
Authors
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May warrant caution with adenovirus vectors in clinical use; leaves open in vivo oncogenicity and evolutionary roles of E4 ORF1.
Human adenovirus E4 ORF1 genes encode growth-transforming proteins that may have evolved from an ancestral adenovirus dUTPase.
Weiss et al. (1997) studied this question.
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