Why the study?
Does eplerenone reduce systolic blood pressure and urinary protein excretion in a rat model of renovascular hypertension?
Population
48 Wistar rats with two-kidney, one-clip (2K-1C) renovascular hypertension
Comparison
Eplerenone 100 mg/kg/day orally, started either… vs Vehicle, sham operation, or Losartan 100…
Design
Preclinical
Follow-up
10 weeks
Authors
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Eplerenone shows promise in rat renovascular hypertension; leaves open translation to human disease.
Does eplerenone reduce systolic blood pressure and urinary protein excretion in a rat model of renovascular hypertension?
In a rat model of renovascular hypertension, eplerenone is as effective as losartan in lowering blood pressure and urinary protein excretion, while also increasing ecNOS gene expression in the heart and aorta.
Hao et al. (2004) studied this question.
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