Why the study?
Does eplerenone reduce blood pressure more effectively than losartan in patients with low-renin hypertension?
Population
168 patients with low-renin hypertension
Comparison
Eplerenone 100 mg once daily initially… vs Losartan 50 mg once daily initially, up-titrated…
Design
RCT, randomized, double-blind
Follow-up
16 weeks
Authors
Loading...
Eplerenone may be preferred over losartan for BP control in low-renin hypertension; extends RCT evidence for MRAs in this subgroup.
Does eplerenone reduce blood pressure more effectively than losartan in patients with low-renin hypertension?
Eplerenone provides greater blood pressure reduction than losartan as monotherapy in patients with low-renin hypertension, supporting its use in this specific sub-population.
M H Weinberger (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: