Why the study?
Is the Leu33/Pro polymorphism (PlAl/PlA2) of the GPIIIa receptor associated with myocardial infarction?
Is the Leu33/Pro polymorphism (PlAl/PlA2) of the GPIIIa receptor associated with myocardial infarction?
The Leu33/Pro polymorphism of the GPIIIa receptor is not associated with myocardial infarction, challenging findings from earlier, smaller studies.
No link to MI risk in this case-control study; challenges smaller prior reports but leaves confirmation to larger prospective cohorts.
Summary The GPIIb/IIIa receptor complex may contribute to acute coronary syndromes by mediating platelet aggregation. The Leu33/Pro polymorphism (PlAl/PlA2) of the GPIIIa has recently been shown to be associated with CHD in a small case-control study. We have investigated this polymorphism in a large multicenter study of patients with myocardial infarction and controls and found no difference in the distribution of allele and genotype frequencies between cases and controls.
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Herrmann et al. (1997) studied this question.
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