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July 1, 1973The Journal of PhysiologyOpen Access

Potassium accumulation in smooth muscle and associated ultrastructural changes

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Population

Mammalian smooth muscles (e.g., taenia coli)

Comparison

Incubation in solutions of varying ionic… vs Normal Krebs solution

Design

Preclinical

Authors

AJAllan JonesThe Open UniversityASA P SomlyoAmpel BioSolutions (United States)ASAvril V. SomlyoVascular / Pulmonary Vascular

Discussion

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Implication

High-KCl solutions may artifactually swell smooth muscle; leaves open optimal depolarizing media for in vitro studies.

Structured PICO

P
Population
Mammalian smooth muscles (e.g., taenia coli)
I
Intervention
Incubation in solutions of varying ionic compositions (e.g., high KCl, high K2SO4) and osmolarities (e.g., addition of sucrose)
C
Comparator
Normal Krebs solution
O
Outcome
Water content, extracellular space, ionic composition, and ultrastructuresurrogate

High KCl solutions cause osmotic swelling and ultrastructural artifacts in mammalian smooth muscle, which can be prevented by adjusting osmolarity or using K2SO4.

Cite This Study

Jones et al. (1973) studied this question.

synapsesocial.com/papers/6a6fa217f44fa9f079dd1954https://doi.org/10.1113/jphysiol.1973.sp010268
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Filament organization in vertebrate smooth muscle1973 · 124 citations
  2. 2Distribution and kinetics of CoEDTA in smooth muscle, and its use as an extracellular marker1969 · 144 citations
  3. 3SARCOPLASMIC RETICULUM AND THE TEMPERATURE-DEPENDENT CONTRACTION OF SMOOTH MUSCLE IN CALCIUM-FREE SOLUTIONS1971 · 160 citations
  4. 4The influence of temperature on the thick filaments of vertebrate smooth muscle1973 · 14 citations
  5. 5SARCOPLASMIC RETICULUM AND EXCITATION-CONTRACTION COUPLING IN MAMMALIAN SMOOTH MUSCLES1972 · 530 citations