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April 1, 1968Acta Physiologica Scandinavica

Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle

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Population

Isolated rat portal vein

Comparison

Variations in extracellular osmolarity vs Normal solution

Design

Preclinical

Authors

BJBörje JohanssonLund UniversityOJOlof JonssonUniversity of Gothenburg

Discussion

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Implication

Cell volume may modulate vascular reactivity; hypothesis-generating in animals and should not change practice.

Structured PICO

P
Population
Isolated rat portal vein
I
Intervention
Variations in extracellular osmolarity (addition of sucrose, xylose, or urea; reduction of Na+ and Cl-)
C
Comparator
Normal solution
O
Outcome
Electrical and mechanical activity (contractile activity and electrical discharge pattern)surrogate

In vascular smooth muscle, cell volume changes directly influence electrical and mechanical activity, with shrinkage causing inhibition and swelling causing excitation.

Cite This Study

Johansson et al. (1968) studied this question.

synapsesocial.com/papers/6a96dc1137dc33ab6afbc9e1https://doi.org/10.1111/j.1365-201x.1968.tb10855.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of the lonic Environment on Spontaneous Electrical and Mechanical Activity of the Rat Portal Vein1967 · 142 citations
  2. 2POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES1943 · 2,809 citations
  3. 3ELECTROKINETIC CONSIDERATIONS OF MECHANOELECTRICAL TRANSDUCTION*1966 · 39 citations
  4. 4Effect of injections of hypertonic solutions on blood flow through the femoral artery of the dog1959 · 60 citations