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February 1, 1981Acta Physiologica Scandinavica

Quantitative aspects of electrical and mechanical responses to anisosmolar solutions in the smooth muscle of the rat portal vein

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Population

Rat portal vein smooth muscle

Comparison

Anisosmolar solutions vs Control solution (290 mosm/kg)

Design

Preclinical

Follow-up

10-15 minutes

Authors

SSStefán B. SigurðssonUniversity of AkureyriBJBörje JohanssonLund University

Discussion

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Implication

Osmolality shifts may alter rat vein force generation; hypothesis-generating for human vascular effects, should not change practice.

Structured PICO

P
Population
Rat portal vein smooth muscle
I
Intervention
Anisosmolar solutions (hypoosmolality by 15 or 30 mosm/kg below control, and hyperosmolality up to 390 mosm/kg, varied by sucrose content)
C
Comparator
Control solution (290 mosm/kg)
O
Outcome
Electrical and mechanical activity (spike discharge and integrated contractile force)surrogate

Changes in osmolality induce dynamic, time-dependent alterations in the electrical and mechanical coupling of rat portal vein smooth muscle.

Cite This Study

Sigurðsson et al. (1981) studied this question.

synapsesocial.com/papers/6a898787abe412682d92ecf0https://doi.org/10.1111/j.1748-1716.1981.tb06714.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tension in Isolated Frog Muscle Fibers Induced by Hypertonic Solutions1973 · 55 citations
  2. 2Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle1968 · 79 citations
  3. 3Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle1968 · 31 citations
  4. 4Contraction of the rat portal vein in hypertonic and isotonic medium: mechanical properties and effects of Mg2+1980 · 15 citations
  5. 5Rate‐dependent Myogenic Response of Vascular Smooth Muscle during Imposed Changes in Length and Force1977 · 28 citations