Why the study?
Does moderate arterial hyperosmolality alter regional vascular resistance and systemic hemodynamics in anesthetized cats?
Does moderate arterial hyperosmolality alter regional vascular resistance and systemic hemodynamics in anesthetized cats?
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Moderate arterial hyperosmolality decreases regional vascular resistance and increases cardiac output, suggesting it plays a role in cardiovascular adjustments during exercise and hemorrhage.
The effects of moderate arterial hyperosmolality (+20 mOsm/kg H2O), produced by short term intravenous hypertonic infusion, on vascular resistance in skin, skeletal muscle, intestine, and kidney were analyzed in the anesthetized cat. Vascular resistance decreased in all four regions in response to the hypertonicity both before and after regional sympathectomy and the effects were not significantly altered by beta-adreno-ceptor blockade. Arterial blood pressure rose during the hypertonic infusion despite the decreased vascular resistance and an unchanged heart rate, indicating an increased stroke volume and cardiac output. Similar increases of arterial osmolality are known to occur in heavy exercise and in hemorrhage. The present results may therefore suggest that blood borne hyperosmolality is a factor which can contribute to the overall cardiovascular adjustments in these situations.
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Jkrhult et al. (1975) studied this question.
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