October 1, 2005AJP Heart and Circulatory Physiology
Interactions of plasma osmolality with arterial and central venous pressures in control of sympathetic activity and heart rate in humans
Why the study?
Do physiological increases in plasma osmolality alter control of muscle sympathetic nerve activity and heart rate in healthy young adults?
Population
17 healthy young adults (7 women, 10 men)
Comparison
Intravenous hypertonic saline during arterial… vs Control condition (baseline)
Design
Other
Authors
Discussion
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Member takes
Implication
Supports osmolality-dependent baroreflex-MSNA modulation in animals; leaves open human translation and clinical relevance.
Structured PICO
Do physiological increases in plasma osmolality alter control of muscle sympathetic nerve activity and heart rate in healthy young adults?
P
Population
17 healthy young adults (7 women, 10 men)
I
Intervention
Intravenous hypertonic saline (1 ml/kg for HT1, 2 ml/kg for HT2) during arterial pressure transients induced by sequential injections of nitroprusside and phenylephrine
C
Comparator
Control condition (baseline)
O
Outcome
Control of muscle sympathetic nerve activity (MSNA) and heart rate (HR)surrogate
Physiological changes in plasma osmolality significantly alter baroreflex control of muscle sympathetic nerve activity and heart rate in humans, an effect modified by central venous and arterial pressures.
Cite This Study
Charkoudian et al. (2005) studied this question.