Key result
Hypertonic saline infusion enhanced baroreflex control of sympathetic outflow compared with isotonic saline infusion (-8.3 vs. -4.0 arbitrary units/beat/mmHg, P=0.01).
Why the study?
Does hypertonic saline infusion increase baroreflex control of sympathetic activity compared to isotonic saline in healthy subjects?
Population
7 healthy subjects, mean age 25 +/- 2 years
Comparison
Hypertonic saline infusion at a rate of 0.15 ml… vs Isotonic saline infusion at a rate of 0.15 ml x…
Design
Other
Follow-up
acute (20 to 40 minutes)
Authors
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Should not alter clinical saline use; hypothesis-generating for baroreflex modulation in autonomic research.
Does hypertonic saline infusion increase baroreflex control of sympathetic activity compared to isotonic saline in healthy subjects?
Absolute Event Rate: -8.3% vs -4%
p-value: p=0.01
Increased plasma osmolality enhances baroreflex control of sympathetic activity in humans when controlling for intravascular volume.
Wenner et al. (2007) studied Healthy (n=7). Hypertonic saline infusion (3% NaCl) vs. Isotonic saline infusion (0.9% NaCl) was evaluated on Baroreflex control of sympathetic outflow (slope of the relationship between MSNA and diastolic blood pressure) (p=0.01). Hypertonic saline infusion enhanced baroreflex control of sympathetic outflow compared with isotonic saline infusion (-8.3 vs. -4.0 arbitrary units/beat/mmHg, P=0.01).
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