What is the clinical evidence from this study?

Study design: Other. Population: Healthy young adults (n=31). Intervention: Hypertonic saline infusion (3% NaCl) vs. Pre-infusion baseline and quiet rest (time control). Primary outcome: Muscle sympathetic nerve activity (MSNA) and blood pressure (BP) responses to handgrip exercise and postexercise ischemia (p=<0.05).

January 8, 2018Journal of NeurophysiologyOpen Access

The influence of acute elevations in plasma osmolality and serum sodium on sympathetic outflow and blood pressure responses to exercise

Q: What are the key findings of this study?

Hypertonic saline infusion acutely increased plasma osmolality and exaggerated muscle sympathetic nerve activity and blood pressure responses during handgrip exercise and postexercise ischemia (P<0.05).

Q: What question did this study set out to answer?

To determine whether acute increases in plasma osmolality and serum sodium exaggerate muscle sympathetic nerve activity and blood pressure responses during handgrip exercise and postexercise ischemia.

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Key result

Hypertonic saline infusion acutely increased plasma osmolality and exaggerated muscle sympathetic nerve activity and blood pressure responses during handgrip exercise and postexercise ischemia (P<0.05).

Why the study?

Does acute hypertonic saline infusion exaggerate muscle sympathetic nerve activity and blood pressure responses to exercise in healthy young adults?

Population

31 healthy young adults, mean age 23 ± 1 yr, BMI 24 ± 1 kg/m2.

Comparison

23-min hypertonic saline infusion followed by… vs Time control protocol consisting of quiet rest…

Design

Other

Follow-up

Acute (during and immediately after 23-min infusion)

Authors

MBMichael S. BrianUniversity of New Hampshire EMEvan L. MatthewsMontclair State University JWJoseph C. WatsoPreventive Cardiology

Discussion

Member takes

Implication

Does not support practice changes; leaves open relevance to salt-sensitive hypertension or heart failure.

Key Points

To determine whether acute increases in plasma osmolality and serum sodium exaggerate muscle sympathetic nerve activity and blood pressure responses during handgrip exercise and postexercise ischemia.
Evaluated muscle sympathetic nerve activity (MSNA) and blood pressure before and after a 23-minute hypertonic saline infusion (3% NaCl) in healthy young adults (n=18, age 23 ± 1 yr).
Assessed cardiovascular and sympathetic responses during isometric handgrip exercise (HG) and postexercise ischemia (PEI), comparing them to a quiet-rest time-control cohort (n=13, age 23 ± 1 yr).
Hypertonic saline infusion increased plasma osmolality (285 ± 1 to 291 ± 1 mosmol/kg H2O, P < 0.05) and serum sodium (138.2 ± 0.3 to 141.3 ± 0.4 mM, P < 0.05), alongside increases in resting mean blood pressure (90 ± 2 to 92 ± 1 mmHg, P < 0.05) and resting MSNA (11 ± 2 to 15 ± 2 bursts/min, P < 0.05).
During HG exercise post-infusion, mean blood pressure (106 ± 2 vs. 111 ± 2 mmHg, P < 0.05), MSNA (20 ± 2 vs. 29 ± 2 bursts/min, P < 0.05), and MSNA change (Δ9 ± 2 vs. Δ13 ± 3 bursts/min, P < 0.05) were significantly elevated, with higher blood pressure (102 ± 2 vs. 107 ± 2 mmHg, P < 0.05) and MSNA (19 ± 2 vs. 24 ± 3 bursts/min, P < 0.05) persisting during PEI.
The time-control group demonstrated no significant alterations in resting or exercise-evoked plasma osmolality, serum sodium, mean blood pressure, or MSNA across the experimental period (all P > 0.05).

Structured PICO

Does acute hypertonic saline infusion exaggerate muscle sympathetic nerve activity and blood pressure responses to exercise in healthy young adults?

Population

31 healthy young adults evaluated for blood pressure and sympathetic nerve activity responses to exercise before and after hypertonic saline infusion or quiet rest.

Intervention

23-min hypertonic saline infusion (3% NaCl) followed by handgrip (HG) exercise and postexercise ischemia (PEI).

Comparator

Time control protocol consisting of quiet rest instead of an infusion, followed by handgrip (HG) exercise and postexercise ischemia (PEI).

Outcome

Muscle sympathetic nerve activity (MSNA) and blood pressure (BP) responses to handgrip (HG) exercise and postexercise ischemia (PEI).surrogate

Main Result

p-value: p=<0.05

Acute elevations in plasma osmolality and serum sodium exaggerate sympathetic nerve activity and blood pressure responses during exercise in healthy young adults.

Cite This Study

Brian et al. (2018) studied Healthy young adults (n=31). Hypertonic saline infusion (3% NaCl) vs. Pre-infusion baseline and quiet rest (time control) was evaluated on Muscle sympathetic nerve activity (MSNA) and blood pressure (BP) responses to handgrip exercise and postexercise ischemia (p=<0.05). Hypertonic saline infusion acutely increased plasma osmolality and exaggerated muscle sympathetic nerve activity and blood pressure responses during handgrip exercise and postexercise ischemia (P<0.05).

synapsesocial.com/papers/6a942d0ac37eedbd3300e30e https://doi.org/10.1152/jn.00559.2017

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The influence of acute elevations in plasma osmolality and serum sodium on sympathetic outflow and blood pressure responses to exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

The influence of acute elevations in plasma osmolality and serum sodium on sympathetic outflow and blood pressure responses to exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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