April 1, 1968Acta Physiologica Scandinavica

Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle

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Population

Isolated rat portal vein (vascular smooth muscle)

Comparison

Variations in extracellular osmolarity vs "Normal" solution

Design

Preclinical

Authors

BJBörje JohanssonLund University OJOlof JonssonUniversity of Gothenburg

Discussion

Member takes

Implication

Cell volume may modulate vascular tone; leaves open relevance to human physiology or therapy.

Structured PICO

Population

Isolated rat portal vein (vascular smooth muscle)

Intervention

Variations in extracellular osmolarity (addition of sucrose, xylose, urea, or reducing osmolarity by decreasing Na+ and Cl-)

Comparator

"Normal" solution

Outcome

Electrical and mechanical activity (contractile activity, electrical discharge pattern)surrogate

In vascular smooth muscle, cell volume changes induced by osmotic variations directly correlate with electrical and mechanical activity, with shrinkage causing inhibition and swelling causing excitation.

Cite This Study

Johansson et al. (1968) studied this question.

synapsesocial.com/papers/6a95d98dacb28a1a8de6ce7d https://doi.org/10.1111/j.1748-1716.1968.tb03870.x

View Full Paper

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Bookmark

Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cell Volume as a Factor Influencing Electrical and Mechanical Activity of Vascular Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider