February 14, 2008Journal of EndocrinologyOpen Access

IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

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Population

Human cardiovascular tissue array and H9c2 cardiomyoblast cell cultures

Design

Preclinical

Authors

CCChun‐Hsien ChuNational Cheng Kung University BTBor‐Show TzangAsia University LCLi-Mien ChenTaichung Armed Forces General Hospital

Discussion

Member takes

Implication

May support IGF2R inhibition to limit hypertrophy; leaves open in vivo efficacy and clinical translation.

Structured PICO

Population

Human cardiovascular tissue array and H9c2 cardiomyoblast cell cultures

Intervention

IGF-II and Leu27IGF-II (an analog of IGF-II)

Outcome

Cell hypertrophy and expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)surrogate

IGF-II/IGF2R signaling induces cardiac hypertrophy and upregulates ANP/BNP via Gαq interaction and PKC-α/CaMKII activation, suggesting IGF2R suppression as a potential therapeutic strategy for pathological hypertrophy.

Cite This Study

Chu et al. (2008) studied this question.

synapsesocial.com/papers/6a6faefd5d37378ac1dcbd6c https://doi.org/10.1677/joe-07-0619

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IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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