Why the study?
Does inhibition of Ras or CYP450 reduce mean arterial blood pressure in rats with Angiotensin II-induced hypertension?
Population
Rats infused with Angiotensin II (350 ng/min for 6 days)
Comparison
Farnesyl protein transferase inhibitor FPT III… vs Angiotensin II plus vehicle
Design
Preclinical
Follow-up
6 days
Authors
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Hypothesis-generating for Ras inhibition in Ang II hypertension; leaves open translation to human therapy.
Does inhibition of Ras or CYP450 reduce mean arterial blood pressure in rats with Angiotensin II-induced hypertension?
Inhibition of Ras and CYP450 pathways attenuates Angiotensin II-induced hypertension and associated vascular pathology in a rat model.
Muthalif et al. (2000) studied this question.
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