Key result
Intracerebroventricular administration of p44/42 MAPK inhibitors PD98059 and UO126 decreased mean arterial pressure, heart rate, and renal sympathetic nerve activity in heart failure rats.
Population
Heart failure rats, sham-operated rats, baroreceptor-denervated rats, and neurally intact rats
Comparison
Intracerebroventricular administration of p44/42… vs Sham-operated rats or baseline conditions
Design
Preclinical
Authors
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Central p44/42 MAPK inhibition reduces sympathetic activity in HF rats; hypothesis-generating for novel sympatholytic strategies pending human data.
Intracellular p44/42 MAPK activity contributes to Angiotensin II-induced neuronal excitation in the paraventricular nucleus of the hypothalamus and augmented sympathetic nerve activity in heart failure rats.
Wei et al. (2008) studied Heart failure. PD98059 and UO126 (p44/42 MAPK inhibitors) vs. Sham-operated rats was evaluated on Mean arterial pressure, heart rate, and renal sympathetic nerve activity. Intracerebroventricular administration of p44/42 MAPK inhibitors PD98059 and UO126 decreased mean arterial pressure, heart rate, and renal sympathetic nerve activity in heart failure rats.
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