Key result
A 4-hour intravenous infusion of aldosterone in rats induced significant increases in renal sympathetic nerve activity, mean blood pressure, and heart rate, which were dependent on AT1R-induced MAPK signaling in the brain.
Why the study?
Does aldosterone induce sympathetic excitation via AT1R-dependent MAPK signaling in the brain in rats?
Population
Male Sprague-Dawley rats (300-350 g)
Comparison
Intravenous infusion of aldosterone combined… vs Intravenous vehicle and/or central vehicle, or…
Design
Preclinical
Follow-up
4 hours
Authors
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No immediate change to aldosterone management in patients; leaves open translation of central AT1R-MAPK effects beyond rodent models.
Does aldosterone induce sympathetic excitation via AT1R-dependent MAPK signaling in the brain in rats?
p-value: p=<0.05
Aldosterone-induced sympathetic excitation depends on AT1R-induced MAPK signaling in the brain, suggesting a rapid, nongenomic mechanism of action.
Yu et al. (2011) studied Sympathetic excitation. Aldosterone vs. Vehicle (0.9% NaCl) was evaluated on Peak increases in integrated renal sympathetic nerve activity (RSNA), mean blood pressure (MBP), and heart rate (HR) (p=<0.05). A 4-hour intravenous infusion of aldosterone in rats induced significant increases in renal sympathetic nerve activity, mean blood pressure, and heart rate, which were dependent on AT1R-induced MAPK signaling in the brain.
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