Key result
Chromosome 2 QTL substitution lowers Dahl S rat systolic blood pressure by up to ~44 mmHg.
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A quantitative trait locus (QTL) for blood pressure was previously detected by linkage analysis in a region of rat chromosome 2 using segregating populations derived from crosses of the Dahl salt-sensitive (Dahl S) rat with rats of the Wistar-Kyoto (WKY) strain or Milan normotensive strain (MNS). Two congenic strains, S.WKY-D2N35/Nep and S.MNS-Adh/D2Mit5, have been constructed by replacing a region of chromosome 2 of the Dahl S rat with the homologous region (ie, low blood pressure QTL allele) of either the WKY or MNS rat, respectively. Systolic pressures of congenic strains S.WKY-D2N35/Nep and S.MNS-Adh/D2Mit5 fed a 2% NaCl diet for 24 days were 44+/-4.6 and 29+/-4.5 mm Hg lower, respectively, than that of the comparably treated Dahl S rats. The differences between congenic and Dahl S rats in blood pressure were highly significant (P<.001) and were corroborated by significantly (P<.001) lower ratio of heart weight to body weight in the congenic strains compared with Dahl S rats. The data from two congenic strains combined unequivocally establish the existence of a blood pressure QTL on rat chromosome 2.
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Deng et al. (1997) studied Blood pressure. Low blood pressure QTL allele on chromosome 2 (congenic strains) vs. Dahl S rats was evaluated on Systolic pressure (44 +/- 4.6 and 29 +/- 4.5 mm Hg lower, p=<.001). Replacing a region of chromosome 2 in Dahl S rats with a homologous low blood pressure QTL allele significantly lowered systolic blood pressure by 29 to 44 mm Hg (P<.001).
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