May 1, 1995Journal of Clinical InvestigationOpen Access

Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.

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Population

F2 populations derived from crosses of inbred Dahl salt-sensitive rats with Milan normotensive rats [n=171]…

Design

Preclinical

Authors

ADAlan Y. DengUniversité de Montréal JRJohn P. RappUniversity of Toledo

Discussion

Member takes

Implication

Supports Nos2 as candidate for rodent salt-sensitive hypertension; leaves open human relevance and mechanistic validation.

Structured PICO

Population

F2 populations derived from crosses of inbred Dahl salt-sensitive (S) rats with Milan normotensive rats (MNS) [n=171] and Wistar-Kyoto (WKY) rats [n=159], fed a high salt (8% NaCl) diet.

Intervention

Genetic mapping and cosegregation analysis of inducible (Nos2) and constitutive (Nos1) nitric oxide synthase loci

Outcome

Systolic blood pressure measured by tail-cuff microphonic manometersurrogate

The inducible nitric oxide synthase locus (Nos2) cosegregates with blood pressure in Dahl salt-sensitive rats, suggesting it as a candidate gene for salt-sensitive hypertension.

Limitations

Cosegregation analysis cannot prove that the Nos2 locus, rather than an unknown linked locus, is the actual QTL for blood pressure
Physiological inferences involving the NO system dependent on an S versus R comparison are probably irrelevant because alleles of Nos2 did not cosegregate with blood pressure in F2(S x R)

Cite This Study

Deng et al. (1995) studied this question.

synapsesocial.com/papers/6a6fafeaac440176ef285887 https://doi.org/10.1172/jci117906

Topics

Hypertension management

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Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider