Population
Dahl/Rapp salt-sensitive rats (S strain) and primary cultures of aortic smooth muscle cells from these rats
Design
Preclinical
Authors
Loading...
NOS2 variant may explain salt-sensitive hypertension in this rat model; leaves open relevance to human disease and requires clinical validation.
Identification of a NOS2 mutation and impaired NO production in Dahl/Rapp rats provides a potential genetic and biochemical basis for their salt-sensitive hypertension.
Chen et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: