October 1, 2000Journal of Hypertension
Tubulointerstitial injury and loss of nitric oxide synthases parallel the development of hypertension in the Dahl-SS Rat
Population
Dahl salt-sensitive (Dahl-SS) and salt-resistant (Dahl-SR) rats
Comparison
Low salt (0.1% NaCl) diet vs Dahl-SR rats
Design
Preclinical
Follow-up
Up to 9 weeks of age
Authors
Discussion
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Implication
Should not change practice; hypothesis-generating for renal NOS and osteopontin roles in salt-sensitive hypertension.
Structured PICO
P
Population
Dahl salt-sensitive (Dahl-SS) and salt-resistant (Dahl-SR) rats
I
Intervention
Low salt (0.1% NaCl) diet
C
Comparator
Dahl-SR rats
O
Outcome
Renal expression of major NOS isoforms (NOS1, -2, and -3) and evidence of renal injurysurrogate
Tubulointerstitial injury and the loss of nitric oxide synthases parallel the development of hypertension in Dahl salt-sensitive rats, suggesting structural and functional renal changes contribute to hypertension.
Cite This Study
Johnson et al. (2000) studied this question.