Amino acids involved in distinguishing between monotypes of rotavirus G serotypes 2 and 4

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Population

Rotavirus strains (serotype G2 and G4, including S2, DS-1, RV-5, RV-6, and 1076)

Design

Preclinical

Authors

Discussion

Should not yet inform rotavirus vaccines or typing; leaves open functional validation in human models.

Population

Rotavirus strains (serotype G2 and G4, including S2, DS-1, RV-5, RV-6, and 1076)

Intervention

Neutralizing monoclonal antibodies (N-MAbs)

Outcome

Amino acid sequence differences correlating with loss of N-MAb reactivity

Specific amino acid mutations in antigenic regions A, B, and C determine the monotype classification of rotavirus G2 and G4 serotypes.

Coulson et al. (1996) studied this question.

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