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November 1, 1997Journal of VirologyOpen Access

Single point mutations may affect the serotype reactivity of serotype G11 porcine rotavirus strains: a widening spectrum?

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Population

Serotype G11 porcine rotavirus strains A253 and YM (single and double neutralization-resistant escape mutants)

Comparison

Single point mutations in antigenic region A and… vs Parental strains (A253 and YM)

Design

Preclinical

Authors

MCMax CiarletNovartis (Switzerland)YHYasutaka HoshinoNational Institute of Infectious DiseasesFLFerdinando LiprandiInstituto Venezolano de Investigaciones Científicas

Discussion

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Overview

May alter G11 rotavirus antigenic profiles in swine; leaves open drivers of dual serotype specificity.

Structured PICO

P
Population
Serotype G11 porcine rotavirus strains A253 and YM (single and double neutralization-resistant escape mutants)
I
Intervention
Single point mutations in antigenic region A (amino acids 87 to 101) and region F (amino acids 235 to 242) of VP7
C
Comparator
Parental strains (A253 and YM)
O
Outcome
Serotype reactivity measured by neutralization assays and ELISAsurrogate

Single point mutations can affect the serotype reactivity of G11 porcine rotavirus strains, potentially explaining the origin of strains with dual serotype specificity.

Cite This Study

Ciarlet et al. (1997) studied this question.

synapsesocial.com/papers/6a6fb30f8031ec7bb1dbe597https://doi.org/10.1128/jvi.71.11.8213-8220.1997
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Also Consider

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  1. 1Serological and genomic characterization of porcine rotaviruses in Thailand: detection of a G10 porcine rotavirus1996 · 69 citations
  2. 2A novel group A rotavirus G serotype: serological and genomic characterization of equine isolate FI231991 · 97 citations
  3. 3Rotavirus serotype G3 predominates in horses1992 · 31 citations
  4. 4The Antigenic Structure of Proteins: A Reappraisal1984 · 952 citations
  5. 5Identification of a New Neutralization Epitope on VP7 of Human Serotype 2 Rotavirus and Evidence for Electropherotype Differences Caused by Single Nucleotide Substitutions1993 · 35 citations