Why the study?
Do ACE inhibitors reduce tissue factor expression in endotoxin-stimulated mononuclear leukocytes?
Do ACE inhibitors reduce tissue factor expression in endotoxin-stimulated mononuclear leukocytes?
ACE inhibitors and angiotensin II AT1 antagonists downregulate tissue factor expression in monocytes, providing a potential mechanistic explanation for their anti-ischemic and antithrombotic clinical benefits.
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May explain antithrombotic benefits of ACEIs/ARBs; leaves open translation from animal models to patients.
Napoleone et al. (2000) studied this question.
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