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December 1, 2008Endocrine Metabolic & Immune Disorders - Drug Targets

Tissue Factor Modulation by Angiotensin II: A Clue to a Better Understanding of the Cardiovascular Effects of Renin-Angiotensin System Blockade?

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Population

Patients with systemic hypertension and other cardiovascular diseases

Design

Review

Authors

ACAlessandro CeliAFAlessandra Del FiorentinoSCSilvana Cianchetti

Discussion

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Overview

May support antithrombotic effects of RAS blockade; leaves open contribution to ischemic event prevention.

Structured PICO

P
Population
Patients with systemic hypertension and other cardiovascular diseases
I
Intervention
Renin-angiotensin system blockers (ACE inhibitors or ARBs)

The protective cardiovascular effects of renin-angiotensin system blockade may be partly mediated by the inhibition of Angiotensin II-induced tissue factor expression, reducing thrombotic risk.

Cite This Study

Celi et al. (2008) studied this question.

synapsesocial.com/papers/6a6f684ffebe604dd7085509https://doi.org/10.2174/187153008786848259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II, tissue factor and the thrombotic paradox of hypertension2010 · 62 citations
  2. 2Angiotensin II Increases Plasminogen Activator Inhibitor-1 and Tissue Factor mRNA Expression without Changing that of Tissue Type Plasminogen Activator or Tissue Factor Pathway Inhibitor in Cultured Rat Aortic Endothelial Cells1997 · 130 citations
  3. 3Mechanisms linking angiotensin II and atherogenesis2002 · 77 citations
  4. 4The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies2009 · 111 citations
  5. 5The renin-angiotensin-aldosterone system: a specific target for hypertension management1999 · 412 citations