Population
Human cultured monocytes isolated from healthy volunteers
Design
Preclinical
Authors
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Animal data suggest ACE inhibitor-specific PAI-1 effects via bradykinin; leaves open translation to human thrombotic outcomes.
ACE inhibitors and AT1 receptor antagonists reduce tissue factor synthesis in human monocytes, but only ACE inhibitors decrease PAI-1 synthesis via a bradykinin-mediated pathway.
Nagata et al. (2001) studied this question.
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