Key result
Angiotensin I, II, and III induced tissue factor and PAI-1 mRNA expression in cultured rat aortic endothelial cells, rendering them thrombogenic, an effect inhibited by an AT1 receptor antagonist.
Why the study?
Do angiotensin metabolites alter the mRNA expression of coagulation and fibrinolysis factors in cultured rat aortic endothelial cells?
Population
Cultured rat aortic endothelial cells
Design
Preclinical
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May promote endothelial thrombogenicity via AT1; hypothesis-generating for human thrombosis risk.
Do angiotensin metabolites alter the mRNA expression of coagulation and fibrinolysis factors in cultured rat aortic endothelial cells?
Angiotensin I, II, and III induce a thrombogenic state in rat aortic endothelial cells by upregulating TF and PAI-1 mRNA via the AT1 receptor.
A 1999 study studied this question. Angiotensin metabolites (Ang I, Ang II, Ang III, Ang IV, Ang 1-7) was evaluated on mRNA expression of TF, TFPI, PAI-1, and TPA. Angiotensin I, II, and III induced tissue factor and PAI-1 mRNA expression in cultured rat aortic endothelial cells, rendering them thrombogenic, an effect inhibited by an AT1 receptor antagonist.
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