November 1, 1990The Journal of Infectious Diseases
Evaluation of WC3 Rotavirus Vaccine and Correlates of Protection in Healthy Infants
Why the study?
Does one dose of WC3 rotavirus vaccine prevent symptomatic rotavirus diarrhea in healthy infants 2-12 months of age?
Population
206 healthy infants 2-12 months of age (n=103 in vaccine group, n=103 in placebo group)
Comparison
One dose of WC3 rotavirus vaccine vs Placebo
Design
RCT, double-blind
Follow-up
during a predominantly serotype 1 rotavirus season
Authors
Discussion
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Member takes
Implication
Single-dose WC3 rotavirus vaccine does not prevent symptomatic diarrhea in infants; challenges single-dose regimens and supports multi-dose evaluation in future trials.
Structured PICO
Does one dose of WC3 rotavirus vaccine prevent symptomatic rotavirus diarrhea in healthy infants 2-12 months of age?
P
Population
206 healthy infants 2-12 months of age (n=103 in vaccine group, n=103 in placebo group)
I
Intervention
One dose of WC3 rotavirus vaccine
C
Comparator
Placebo
O
Outcome
Number of symptomatic episodes of rotavirus diarrhea and number of moderate to severe rotavirus illnesseshard clinical
A single dose of WC3 rotavirus vaccine was safe and immunogenic but did not significantly reduce the overall incidence of symptomatic rotavirus diarrhea in healthy infants.
Cite This Study
Bernstein et al. (1990) studied this question.