Why the study?
Does selective IgA deficiency affect the resolution of rotavirus disease and antibody responses compared to IgA proficient individuals?
Does selective IgA deficiency affect the resolution of rotavirus disease and antibody responses compared to IgA proficient individuals?
IgA is not essential for resolving rotavirus disease in humans, as IgA-deficient individuals can resolve the disease and develop higher IgG and IgG1 titers.
May not impair rotavirus resolution; leaves open compensatory IgG roles and requires prospective validation.
While IgA is proposed to be essential to control rotavirus disease, no information is available how IgA deficient individuals modulate rotavirus disease and immune responses. In this study it was shown that patients (n = 62) with selective IgA deficiency (IgA-D) (<0.05 g/L) resolve rotavirus disease and show higher total IgG and IgG1 subclass antibody titers to rotavirus than IgA proficient individuals (n = 62) (geometric mean titer, GMT) 18,101 vs. 4,000 (P < 0.005); 8,463 vs. 1691, (P < 0.005). It is concluded that IgA is not essential for resolving rotavirus disease in humans.
No takes yet. Share an insight, caveat, or question.
Istrate et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: