Why the study?
Does serum rotavirus specific IgA correlate with protection against rotavirus infection in children vaccinated with RRV-TV compared to naturally infected children?
Does serum rotavirus specific IgA correlate with protection against rotavirus infection in children vaccinated with RRV-TV compared to naturally infected children?
Serum rotavirus IgA correlates with protection in children pre-exposed to natural infection but not in those immunized with the RRV-TV vaccine.
Serum rotavirus IgA was associated with protection only after natural infection; leaves open its utility as a correlate post-vaccination.
To directly compare serum rotavirus specific IgA as a marker of protection in children vaccinated with the RRV-TV (Rotashield) vaccine and in naturally infected children, we studied pre-existing rotavirus IgA antibodies by ELISA assays in these groups of children within the first 5 days after the onset of a diarrhea episode, due or not to rotavirus. In immunized children, rotavirus IgA titers were similar between infected and non-RV infected children. In non-immunized children, the proportion with rotavirus IgA titers was significantly greater in non-RV infected children (58%) than in infected children (31%). Additionally, a titer >/=1:800 was associated with 68% protection. Thus, in this study serum rotavirus IgA showed a good correlation with protection in children pre-exposed to natural infection but not in those immunized with the RRV-TV vaccine.
No takes yet. Share an insight, caveat, or question.
González et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: