Population
Mice with a cardiomyocyte-restricted knockout of STAT3, neonatal rat cardiomyocytes, rat cardiac endothelial…
Design
Preclinical
Authors
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May implicate STAT3-miR-199a signaling in experimental HF; hypothesis-generating and requires human validation before clinical relevance.
The study identifies a novel pathophysiological circuit in heart failure where reduced STAT3 increases miR-199a, impairing the ubiquitin-proteasome system and endothelial function.
Haghikia et al. (2010) studied this question.
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