Why the study?
The association of angiotensin-converting enzyme 2 (ACE2) with vascular endothelial injury in Kawasaki disease and its prognostic potential for vascular injury had not yet been assessed.
Are serum ACE2 levels elevated in children with Kawasaki disease compared to healthy controls?
Are serum ACE2 levels elevated in children with Kawasaki disease compared to healthy controls?
Serum ACE2 levels are significantly elevated in children with Kawasaki disease and negatively correlate with platelet levels, suggesting a potential role as a biomarker for vascular injury.
Kawasaki disease (KD) has replaced rheumatic fever as the main cause of acquired heart disease in Japanese, American, and Chinese children. Polymorphisms in angiotensin-converting enzyme may be associated with susceptibility to KD, but the association of angiotensin-converting enzyme 2 (ACE2) with vascular endothelial injury in KD and the possibility for prognosis of vascular injury in KD by evaluating changes in serum ACE2 have not yet been assessed. Thus, this study aimed to investigate ACE2 levels in patients with KD to further explore the relationship between ACE2 and vascular injury in KD. Blood samples were collected from 49 children with KD before intravenous immunoglobulin treatment and 28 healthy children in the same period as the control group. Clinical data were collected from the patients and serum ACE2 levels of all participants were measured using an enzyme-linked immunosorbent assay. Serum ACE2 levels were significantly higher in the KD group than in the control group, and were negatively correlated with platelet levels in patients with KD. Serum ACE2 levels are related to the pathogenesis of KD and may be used as a potential serum marker for KD diagnosis.
No takes yet. Share an insight, caveat, or question.
Gan et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: