Key result
Polymorphisms in the ANGPT1 (P=2.3×10^-7) and VEGFA (P=2.5×10^-4) genes were significantly associated with Kawasaki disease susceptibility.
Why the study?
Are genetic variants in VEGF and ANGPT associated with Kawasaki disease susceptibility and vascular homeostasis disruption?
Population
574 families for initial genotyping, and 123 cases and 171 controls for replication. Patients with Kawasaki…
Comparison
Genotyping of 292 single-nucleotide… vs Healthy controls, controls with/without fever…
Design
Case-control
Authors
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May refine KD genetic risk models; leaves open clinical translation pending validation.
Case-Control
Are genetic variants in VEGF and ANGPT associated with Kawasaki disease susceptibility and vascular homeostasis disruption?
p-value: p=2.3×10(-7)
Genetic variants in ANGPT1 and VEGFA are associated with Kawasaki disease susceptibility, supporting the role of dysregulated vascular homeostasis in its pathogenesis.
Breunis et al. (2011) conducted a case-control in Kawasaki disease. Genetic variants in ANGPT1 and VEGFA vs. Controls / Wild-type alleles was evaluated on Kawasaki disease susceptibility (p=2.3×10(-7)). Polymorphisms in the ANGPT1 (P=2.3×10^-7) and VEGFA (P=2.5×10^-4) genes were significantly associated with Kawasaki disease susceptibility.
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