Why the study?
Do skeletal muscle metabolic abnormalities in the arm and leg muscles correlate with systemic exercise intolerance in patients with chronic heart failure?
Population
13 patients with chronic heart failure and 11 age- and size-matched normal controls. Mean age 52±12 for CHF…
Comparison
Calf-plantar and forearm-wrist flexion exercise… vs Normal controls
Design
Cross-sectional
Authors
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Muscle PCr kinetics associate with exercise intolerance in CHF; leaves open whether peripheral targets improve outcomes.
Do skeletal muscle metabolic abnormalities in the arm and leg muscles correlate with systemic exercise intolerance in patients with chronic heart failure?
Metabolic abnormalities during exercise are present in both arm and leg muscles of patients with chronic heart failure, but leg muscle abnormalities are more closely related to systemic exercise intolerance.
Nagai et al. (2004) studied this question.
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