Why the study?
What is the pharmacokinetic and pharmacodynamic relationship between quinidine plasma concentrations and electrocardiographic intervals after oral and i.v. doses in normal subjects?
Population
10 normal subjects
Design
Other
Authors
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Active metabolites may explain greater oral quinidine QT effects; hypothesis-generating and should not yet alter practice.
What is the pharmacokinetic and pharmacodynamic relationship between quinidine plasma concentrations and electrocardiographic intervals after oral and i.v. doses in normal subjects?
The greater pharmacodynamic effect of oral versus intravenous quinidine on the QT interval suggests the formation of active metabolites during gastrointestinal absorption.
Holford et al. (1981) studied this question.
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