Why the study?
Does quinidine sulfate alter QRS duration, QT interval, and systolic time intervals in healthy volunteers?
Population
7 healthy volunteers (5 male, 2 female) in a fasting state
Comparison
Quinidine sulfate 400 mg vs Control period
Design
Other
Follow-up
7 hours
Authors
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Alerts to QTc prolongation risk even at low quinidine levels; leaves open arrhythmic implications for patients pending larger studies.
Does quinidine sulfate alter QRS duration, QT interval, and systolic time intervals in healthy volunteers?
Quinidine administration significantly prolongs the QT interval and total electromechanical systole even at low plasma levels in healthy volunteers.
Fieldman et al. (1977) studied this question.
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