Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2011Frontiers in PharmacologyOpen Access

Targeting GIRK Channels for the Development of New Therapeutic Agents

View Full Paper
Ask AI
Bookmark
Share

Population

Pituitary (AtT20) and cardiac (HL-1) cell lines expressing GIRK channels

Comparison

Compound library of Na and K channel modulators… vs Control (and known inhibitors Ba and tertiapin-Q)

Design

Preclinical

Authors

KWKenneth B. WalshMercy Medical Center

Discussion

Loading...

Member takes

Implication

May support GIRK-targeted arrhythmia therapies; leaves open translation from animal screening to clinical use.

Structured PICO

P
Population
Pituitary (AtT20) and cardiac (HL-1) cell lines expressing GIRK channels
I
Intervention
Compound library of Na(+) and K(+) channel modulators (including 5-(N,N-hexamethylene)-amiloride and SCH-28080)
C
Comparator
Control (and known inhibitors Ba(2+) and tertiapin-Q)
O
Outcome
Fluorescent signal indicative of K(+) efflux through GIRK channelssurrogate

A novel fluorescent screening assay successfully identified new GIRK channel blockers, providing a tool for developing therapeutic agents for GIRK channelopathies such as cardiac arrhythmias.

Cite This Study

Kenneth B. Walsh (2011) studied this question.

synapsesocial.com/papers/6a6fbcafe5469ee92be096c0https://doi.org/10.3389/fphar.2011.00064
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Novel High-Affinity Inhibitor for Inward-Rectifier K + Channels1998 · 229 citations
  2. 2Antiarrhythmic agents act differently on the activation phase of the ACh‐response in guinea‐pig atrial myocytes1993 · 47 citations
  3. 3A Real-Time Screening Assay for GIRK1/4 Channel Blockers2010 · 14 citations
  4. 4A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays1999 · 7,043 citations
  5. 5HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes2010 · 18 citations