Key result
G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have emerged as mediators of cardiac dynamics and represent a potential therapeutic target for cardiovascular conditions.
Why the study?
Although GIRK channels are known to be a main factor in heart control, their therapeutic potential in cardiac conditions has remained largely untapped.
This review highlights the emerging role of GIRK/Kir3 channels in cardiac dynamics and their potential as therapeutic targets for cardiovascular conditions.
Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated following the modulation of G-protein-coupled receptors and, although they have been implicated in different neurological diseases in both human and animal studies of the central nervous system, the therapeutic potential of different subtypes of these channel families in cardiac conditions has remained untapped. As they have emerged as a promising potential tool to treat a variety of conditions that disrupt neuronal homeostasis, many studies have started to focus on these channels as mediators of cardiac dynamics, thus leading to research into their implication in cardiovascular conditions. Our aim is to review the latest advances in GIRK modulation in the heart and their role in the cardiovascular system.
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Campos-Ríos et al. (2022) conducted a review in Cardiovascular conditions. GIRK channels modulation was evaluated. G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have emerged as mediators of cardiac dynamics and represent a potential therapeutic target for cardiovascular conditions.
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