DN-MSTN TG13 mice represent a novel preclinical model of atrial fibrillation associated with cardiac hypertrophy, characterized by early loss of Cx40 prior to the development of fibrosis.
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Transgenic mice show higher AF rates than WT; hypothesis-generating for a novel hypertrophy-linked model, no clinical implications yet.
Rosenberg et al. (2012) studied this question.
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